Clinical evidence

Every dose is verifiable against
the published literature.

The five primary studies cited in the Metabolic Reset formulation. Each entry includes the trial design, the dose examined, and the specific outcome that informs the ingredient's inclusion.

01

Berberine meta-analysis: blood glucose and lipid markers

Lan J, Zhao Y, Dong F, et al. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161:69-81.

Population Adults with type 2 diabetes, hyperlipidaemia, or hypertension across 46 randomised controlled trials
Intervention Berberine supplementation at various doses. The dose range consistent with the Metabolic Reset formulation (around 90-100 mg per serve) falls within the doses studied.
Outcome Significant reductions in fasting blood glucose, postprandial blood glucose, HbA1c, total cholesterol, LDL-cholesterol, and triglycerides compared to control. Safety profile comparable to standard treatments in the populations studied.
Relevance to Metabolic Reset Berberine in Metabolic Reset is delivered via BioBerb® with LipiSperse® technology to support bioavailability. The AMPK activation mechanism identified in the trials underpins the blood sugar balance and lipid metabolism claims on this product.
Additional references
02

B420® probiotic RCT: gut barrier and body composition

Stenman LK, Lehtinen MJ, Meland N, et al. (2016). Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults: A Randomized Controlled Trial. eBioMedicine, 13:190-200.

Population 225 overweight and obese adults (BMI 25-35) in a double-blind, placebo-controlled, randomised trial over 6 months
Intervention Bifidobacterium lactis B420® at 10 billion CFU (approximately 12.5 mg) daily, with or without prebiotic fibre
Outcome Significant reduction in body fat mass and waist circumference versus placebo. Serum zonulin (a marker of intestinal permeability) was reduced, confirming the gut barrier integrity mechanism. The probiotic-alone arm showed significant body fat management effects independent of fibre.
Relevance to Metabolic Reset B420® in Metabolic Reset is included at 12.5 mg per serve, the same dose and strain used in this RCT. This is the only probiotic with a double-blind RCT specifically designed to examine body composition outcomes at this dose and duration.
Additional references
03

Green tea catechins meta-analysis: fat oxidation and body weight

Hursel R, Viechtbauer W, Westerterp-Plantenga MS. (2009). The effects of green tea on weight loss and weight maintenance: a meta-analysis. International Journal of Obesity, 33(9):956-961.

Population Adults across 11 randomised controlled trials examining green tea catechins and body weight or weight maintenance
Intervention Green tea catechin supplementation at standardised EGCG doses, including doses equivalent to the 6380 mg dry herb equivalent used in Metabolic Reset
Outcome Significant positive effect on fat oxidation and body weight maintenance. Effects were most pronounced without habitual caffeine intake. The meta-analysis identified catechin-driven fat oxidation via COMT inhibition as the primary mechanism.
Relevance to Metabolic Reset Green Tea Extract in Metabolic Reset is standardised for EGCG content. The COMT inhibition mechanism identified in this meta-analysis supports the fat oxidation claim associated with this ingredient at this dose.
Additional references
04

Resveratrol 75 mg RCT: SIRT1 activation and metabolic effects

Timmers S, Konings E, Bilet L, et al. (2011). Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans. Cell Metabolism, 14(5):612-622.

Population 11 obese but otherwise healthy male adults in a double-blind, placebo-controlled crossover trial
Intervention Trans-resveratrol at 150 mg per day (two 75 mg doses), matched to the 75 mg per serve in Metabolic Reset, for 30 days
Outcome Measurable SIRT1 activation in skeletal muscle. Improved mitochondrial function (AMPK phosphorylation, increased mitochondrial density). Reduced fasting plasma glucose, insulin, and triglycerides. Improved fat oxidation during rest. Authors characterised effects as resembling caloric restriction at the cellular level.
Relevance to Metabolic Reset Resveratrol in Metabolic Reset is included at 75 mg per serve, the per-dose equivalent used in this trial. SIRT1 activation by resveratrol operates through a distinct upstream pathway from berberine's AMPK mechanism, providing complementary metabolic support.
Additional references
05

Chromium picolinate systematic review: insulin sensitivity

Abdulrahman M. (2021). Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of glycaemic and oxidative stress. Clinical and Experimental Pharmacology and Physiology, 48(4):467-478.

Population Adults examined in studies on chromium picolinate's role in glycaemic regulation and oxidative stress modulation
Intervention Chromium picolinate supplementation at doses consistent with established NRV guidelines, including the 0.1 mg per serve used in Metabolic Reset
Outcome Chromium picolinate supported insulin receptor sensitivity through chromodulin-mediated potentiation of insulin receptor tyrosine kinase activity. Improved glycaemic markers and reduced oxidative stress markers in populations with metabolic challenges.
Relevance to Metabolic Reset Chromium in Metabolic Reset addresses insulin receptor sensitivity through a direct receptor-level mechanism, complementing berberine's upstream AMPK pathway. The two ingredients together address insulin signalling from two mechanistically distinct angles.
Additional references
06

Ginger extract RCT: glycaemic control and insulin sensitivity

Arablou T, Aryaeian N, Valizadeh M, et al. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition, 65(4):515-520.

Population Adults with type 2 diabetes in a randomised, double-blind, placebo-controlled trial over 8 weeks
Intervention Ginger supplementation at 1600 mg per day, equivalent to the dose in Metabolic Reset. The active constituents are gingerols and shogaols.
Outcome Significant reductions in fasting plasma glucose, HbA1c, insulin concentration, and HOMA-IR versus placebo. Improvements in lipid profile and reductions in inflammatory markers (TNF-α, IL-6) were also observed.
Relevance to Metabolic Reset Ginger Extract in Metabolic Reset targets the gut-metabolic axis through gingerol-mediated improvements in gastric motility and insulin sensitivity. The anti-inflammatory mechanism identified in this trial complements the AMPK and SIRT1 pathways targeted by berberine and resveratrol.
Additional references

These references are provided for transparency and education. Citations relate to ingredient-level research; they do not constitute a claim that Metabolic Reset treats, cures, or prevents any disease or medical condition. Maison Belasi makes structure/function claims only, in accordance with NZ Dietary Supplements Regulations 1985 and TGA guidelines.

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